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Safety of Endoscopic Ultrasound-Guided Fine-Needle Aspiration for Pancreatic Solid Pseudopapillary Neoplasm Before Surgical Resection

2019; Lippincott Williams & Wilkins; Volume: 49; Issue: 1 Linguagem: Inglês

10.1097/mpa.0000000000001460

1536-4828

David Karsenti, Fabrice Caillol, Ulriikka Chaput, Bastien Perrot, Stéphane Koch, Lucine Vuitton, Jérémie Jacques, Jean-Christophe Valats, Laurent Poincloux, C. Subtil, Édouard Chabrun, Nicolas Williet, Geoffroy Vanbiervliet, Hichem Belkhodja, Antoine Charachon, Marc Wangermez, Emmanuel Coron, Franck Cholet, Jocelyn Privat, Yann Le Baleur, Philippe Bichard, Philippe Ah Soune, Stéphane Lecleire, Maxime Palazzo,

Pancreatitis Pathology and Treatment

Objectives The results of only a few endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) for pancreatic solid pseudopapillary neoplasm (SPN) have been published, and the safety of the procedure has never been investigated. Our study compared the recurrence rate in patients with and without preoperative EUS-FNA. Methods This European multicenter registry-based study was conducted in 22 digestive units, and retrospectively included all patients who underwent complete resection of a pancreatic SPN from 2000 to 2018. Patients with and without initial EUS-FNA were compared, and postsurgery recurrence and the associated risk factors were evaluated. Results A complete resection of a pancreatic SPN was performed in 149 patients (133 women, 89%), with a mean age of 34 (standard deviation, 14) years. There were no significant differences between the with (78 patients) and without (71 patients) EUS-FNA groups, except for age and tumor size and location. Preoperative EUS-FNA allowed pancreatic SPN diagnosis in 63/78 cases (81%). After a mean follow-up of 43 (standard deviation, 36) months, recurrence was noted in 4 patients (2.7%). Preoperative EUS-FNA was not correlated with recurrence, but an older age ( P = 0.005) was significant. Conclusions Preoperative EUS-FNA does not affect pancreatic SPN recurrence. In this series, old age was significantly correlated with recurrence.