Overview of recent developments of pyrazole derivatives as an anticancer agent in different cell line
2019; Elsevier BV; Volume: 97; Linguagem: Inglês
10.1016/j.bioorg.2019.103470
ISSN1090-2120
AutoresFatima Ezzahra Bennani, Latifa Doudach, Yahia Cherrah, Youssef Ramli, Khalid Karrouchi, M’hammed Ansar, My El Abbés Faouzi,
Tópico(s)Click Chemistry and Applications
ResumoPyrazole is a five-membered aromatic heterocyclic ring with two adjacent nitrogen atoms C3H3N2H.The presence of this nucleus in pharmacological agents of various therapeutic categories gifts a broad spectrum of biological activities and pharmaceuticals that contain pyrazole like celecoxib (anti-inflammatory), CDPPB (antipsychotic), Rimonabant (anti-obesity), Difenamizole, (Analgesic), Betazole (H2 receptor agonist), Fezolamide (Antidepressant), etc… The pharmacological potential of the pyrazole fraction is proved in many publication where they synthesized and evaluated pyrazoles against several biological agents. The aim of this article review is to survey recent works linking pyrazole structures to anticancer activities corresponding to 9 different type of cancer.
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