Produção Nacional
Revisado por pares
Water-Soluble Glutamic Acid Derivatives Produced in Culture by Penicillium solitum IS1-A from King George Island, Maritime Antarctica
2020; American Chemical Society; Volume: 83; Issue: 1 Linguagem: Inglês
10.1021/acs.jnatprod.9b00635
ISSN1520-6025
AutoresJulie Paulin García Rodríguez, Darlon I. Bernardi, Juliana R. Gubiani, Juliana Magalhães de Oliveira, Raquel P. Morais‐Urano, Ariane F. Bertonha, Karin F. Bandeira, Jairo I. Q. Bulla, Lara Durães Sette, Antônio G. Ferreira, João M. Batista, Thayná S. Silva, Raquel Alves dos Santos, Carlos Henrique Gomes Martins, Simone Possedente de Lira, Marcos Guilherme da Cunha, Daniela Barretto Barbosa Trivella, Nathália Grazzia, Natália E. S. Gomes, Fernanda Ramos Gadelha, Danilo C. Miguel, Ana Carolina Guimarães Cauz, Marcelo Brocchi, Roberto G. S. Berlinck,
Tópico(s)Marine Sponges and Natural Products
ResumoA new method of screening was developed to generate 770 organic and water-soluble fractions from extracts of nine species of marine sponges, from the growth media of 18 species of marine-derived fungi, and from the growth media of 13 species of endophytic fungi. The screening results indicated that water-soluble fractions displayed significant bioactivity in cytotoxic, antibiotic, anti-Leishmania, anti-Trypanosoma cruzi, and inhibition of proteasome assays. Purification of water-soluble fractions from the growth medium of Penicillium solitum IS1-A provided the new glutamic acid derivatives solitumine A (1), solitumine B (2), and solitumidines A–D (3–6). The structures of compounds 1–6 have been established by analysis of spectroscopic data, chemical derivatizations, and vibrational circular dichroism calculations. Although no biological activity could be observed for compounds 1–6, the new structures reported for 1–6 indicate that the investigation of water-soluble natural products represents a relevant strategy in finding new secondary metabolites.
Referência(s)