Produção Nacional
Revisado por pares
Halogenated Diterpenes with In Vitro Antitumor Activity from the Red Alga Sphaerococcus coronopifolius
2019; Multidisciplinary Digital Publishing Institute; Volume: 18; Issue: 1 Linguagem: Inglês
10.3390/md18010029
ISSN1660-3397
AutoresVangelis Smyrniotopoulos, Anna Cláudia de Andrade Tomaz, María de Fátima Vanderlei de Souza, Emídio Vasconcelos Leitão da Cunha, Róbert Kiss, Véronique Mathieu, Efstathia Ioannou, Vassilios Roussis,
Tópico(s)Marine Sponges and Natural Products
ResumoEight new (1–8) structurally diverse diterpenes featuring five different carbocycles were isolated from the organic extracts of the red alga Sphaerococcus coronopifolius collected from the coastline of the Ionian Sea in Greece. The structures of the new natural products, seven of which were halogenated, and the relative configuration of their stereocenters were determined on the basis of comprehensive spectroscopic analyses, including NMR and HRMS data. Compounds 5 and 8 were found to possess in vitro antitumor activity against one murine and five human cancer cell lines with mean IC50 values 15 and 16 μM, respectively.
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