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FOXP3+ and CD25+ cells are reduced in patients with stage IV, grade C periodontitis: A comparative clinical study

2019; Wiley; Volume: 55; Issue: 3 Linguagem: Inglês

10.1111/jre.12721

1600-0765

Raphael Jurca Gonçalves da Motta, Luciana Yamamoto Almeida, Kelly Rocio Vargas Villafuerte, Alfredo Ribeiro‐Silva, Jorge Esquiche León, Camila Tirapelli,

Oral Health Pathology and Treatment

Abstract Background and Objective Some studies suggest that regulatory T cells (Tregs) have suppressive effects on inflammatory osteolysis. The aim of this study was to evaluate Treg immunomarkers in periodontitis‐affected tissues from patients with periodontitis and clinically healthy gingiva (control). Material and Methods The presence and distribution of positive cells for CD4, CD25 and FOXP3 (Treg immunomarkers) in periodontitis‐affected tissues (epithelium and lamina propria) of 30 patients (ten per group) with a diagnosis of stage IV, grade C periodontitis (IV‐C), stage III, grade B periodontitis (III‐B) and the control were evaluated. A two‐way ANOVA followed by Fisher's LSD test was used to demonstrate differences between the groups and immunomarkers; Student's t test was used to demonstrate differences between the epithelium and the lamina propria. Results Both IV‐C and III‐B periodontitis presented a significantly high proportion of immune‐stained cells for all immunomarkers when compared to the control group. Notably, CD25+ and FOXP3+ cells were detected in a significantly higher number in III‐B than IV‐C periodontitis ( P < .05). Conclusion Our results suggest the participation of Tregs on the osteoimmunological mechanisms in IV‐C and III‐B periodontitis patients, notably contributing to strategies for alveolar bone regeneration in clinical treatment decisions.