Portal de Periódicos da CAPES

Survivors of Ebola Virus Disease Develop Polyfunctional Antibody Responses

2019; Oxford University Press; Volume: 221; Issue: 1 Linguagem: Inglês

10.1093/infdis/jiz364

1537-6613

Bronwyn M. Gunn, Vicky Roy, Marcus M. Karim, Jessica N. Hartnett, Todd J. Suscovich, Augustine Goba, Mambu Momoh, John Demby Sandi, Lansana Kanneh, Kristian G. Andersen, Jeffrey G. Shaffer, John S. Schieffelin, Robert F. Garry, Donald S. Grant, Galit Alter,

COVID-19 epidemiological studies

Abstract Monoclonal antibodies can mediate protection against Ebola virus (EBOV) infection through direct neutralization as well as through the recruitment of innate immune effector functions. However, the antibody functional response following survival of acute EBOV disease has not been well characterized. In this study, serum antibodies from Ebola virus disease (EVD) survivors from Sierra Leone were profiled to capture variation in overall subclass/isotype abundance, neutralizing activity, and innate immune effector functions. Antibodies from EVD survivors exhibited robust innate immune effector functions, mediated primarily by IgG1 and IgA1. In conclusion, development of functional antibodies follows survival of acute EVD.