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Cortical pattern generation during dexterous movement is input-driven

2019; Nature Portfolio; Volume: 577; Issue: 7790 Linguagem: Inglês

10.1038/s41586-019-1869-9

1476-4687

Britton Sauerbrei, Jian‐Zhong Guo, Jeremy D. Cohen, Matteo Mischiati, Wendy Guo, Mayank Kabra, Nakul Verma, Brett D. Mensh, Kristin Branson, Adam W. Hantman,

EEG and Brain-Computer Interfaces

The motor cortex controls skilled arm movement by sending temporal patterns of activity to lower motor centres1. Local cortical dynamics are thought to shape these patterns throughout movement execution2–4. External inputs have been implicated in setting the initial state of the motor cortex5,6, but they may also have a pattern-generating role. Here we dissect the contribution of local dynamics and inputs to cortical pattern generation during a prehension task in mice. Perturbing cortex to an aberrant state prevented movement initiation, but after the perturbation was released, cortex either bypassed the normal initial state and immediately generated the pattern that controls reaching or failed to generate this pattern. The difference in these two outcomes was probably a result of external inputs. We directly investigated the role of inputs by inactivating the thalamus; this perturbed cortical activity and disrupted limb kinematics at any stage of the movement. Activation of thalamocortical axon terminals at different frequencies disrupted cortical activity and arm movement in a graded manner. Simultaneous recordings revealed that both thalamic activity and the current state of cortex predicted changes in cortical activity. Thus, the pattern generator for dexterous arm movement is distributed across multiple, strongly interacting brain regions. The complex patterns of activity in motor cortex that control movements such as reach and grasp are dependent on both upstream neuronal activity in the thalamus and the current state of the cortex.