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Prognosis Prediction of Pancreas Cancer using Textural Analysis Parameters derived from F-18 FDG PET/CT

2015; Society of Nuclear Medicine and Molecular Imaging; Volume: 56; Linguagem: Inglês

1535-5667

Min‐Kyung So, Won Woo Lee, Min Young Yoo, Yoo‐Seok Yoon, Jai Young Cho, Ho‐Seong Han, Sang Eun Kim,

Medical Imaging Techniques and Applications

1411 Objectives We evaluated the prognosis prediction ability of textural analysis parameters derived from preoperative F-18 FDG PET/CT in operable pancreas cancer patients. Methods Sixty pancreas cancer patients (m:f=36:24, age=67±9 yrs) who had undergone F-18 FDG PET/CT prior to the surgery were enrolled. Surgico-pathologic parameters, postop treatment, PET parameters (SUVmax, glucose-incorporated SUVmax=GI-SUVmax, metabolic tumor volume=MTV, total-lesion glycolysis=TLG), and a number of textural parameters were compared with survival. 3D textural analysis was performed using imaging analysis software (MaZda version 4.6). Results All the patients had R0 resection. 37 (m:f=26:11, age 66 ± 11 yrs) patients died at 16.73±8.81 months after the operation, whereas 23 (m:f=10:13, age 69 ± 10 yrs) survived with the follow-up duration of 20.02±11.74 months. In the univariate analysis, concomitant operation (p=0.0003), tumor size (p=0.0019), GI-SUVmax with a cutoff of 600 (p=0.0030), blood loss amount (p=0.0212), portal invasion (p=0.0280), postop radiotherapy (p=0.0337) and number of metastatic lymph nodes (p=0.0481) were significant parameters for survival. Among the textural parameters, VolumeS(4,-4,0) (p=0.0479), Kurtosis3D (p=0.0518), VolumeS(5,0,0) (p=0.0575), Skewness3D (p=0.0635), VolumeS(4,0,0) (p=0.080), VolumeS(5,-5,0) (p=0.0986), and VolumeS(5,5,0) (p=0.0986) were potentially significant predictors in the univariate analysis. However, all the textural parameters having significancy in the univariate analysis did not remain in the multivariate analysis. Only GI-SUVmax with a cutoff of 600 (p=0.0001), tumor size (p=0.0060), and concomitant operation (p=0.0043) were significant predictors of survival. Conclusions The current research result indicates that the textural analysis of F-18 FDG PET/CT has a limited performance for survival prediction of operable pancreas cancer.