Produção Nacional
Revisado por pares
Per oral rat treatment with glyconjugate fractions of Genipa americana leaves protects thrombus formation
2020; Lippincott Williams & Wilkins; Volume: 31; Issue: 1 Linguagem: Inglês
10.1097/mbc.0000000000000880
ISSN1473-5733
AutoresJuliana C. Madeira, Luis A.S. Farias, Camila P. Luz, Ana Maria Sampaio Assreuy, Maria Gonçalves Pereira,
Tópico(s)Natural Antidiabetic Agents Studies
ResumoThe current study evaluated the effect of the arabinogalactan-glycoconjugate fractions (FI and FII) isolated from Genipa americana leaves given per oral in rat hemostasis protocols. Rats received daily treatment with FI or FII during 7 days and were evaluated for coagulation, platelet aggregation, venous thrombosis and bleeding tendency 1 h after the last treatment. FII prolonged in 5.5-fold the rat plasma coagulation time (activated partial thromboplastin time test). FI inhibited by 46% the platelet aggregation. Both FI and FII prevented thrombus formation by 33 and 28%, respectively. However, the bleeding time was not altered by any fractions, showing an advantage in relation to acetylsalicylic acid or warfarin that increased the bleeding time in 3.6 and 2.9-fold, respectively. Per oral treatment with the arabinogalactan-glyconjugate fractions FI and FII of G. americana leaves in rats prevents thrombus formation, being devoid of hemorrhagic risk. These results bring novel therapeutic possibilities for thromboembolic diseases.
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