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Artigo Produção Nacional Revisado por pares
BIBTEX RIS

Anxiolytic and antidepressant-like effects of Annona coriacea (Mart.) and caffeic acid in mice

2019; Elsevier BV; Volume: 136; Linguagem: Inglês

10.1016/j.fct.2019.111049

ISSN

1873-6351

Autores

Álefe Brito Monteiro, Cristina Kelly de Souza Rodrigues, Emmily Petícia do Nascimento, Valterlúcio dos Santos Sales, Gyllyandeson de Araújo Delmondes, Maria Haiele Nogueira da Costa, Victor Afonso Pereira de Oliveira, Luís Pereira-de-Morais, Aline Augusti Boligon, Roseli Barbosa, José Galberto Martins da Costa, Irwin Rose Alencar de Menezes, Cícero Francisco Bezerra Felipe, Marta Regina Kerntopf,

Tópico(s)

Biochemical Analysis and Sensing Techniques

Resumo

This research evaluated the anxiolytic and antidepressant-like effects of a hydroethanolic extract from the leaves of Annona coriacea (EHFAC) and caffeic acid (CA). Mice were intraperitoneally treated with saline, EHFAC (1, 10, 20 mg/kg) or CA (0.15 mg/kg) and subject to the elevated plus-maze, open field, rota-rod, forced swimming and reserpine-induced akinesia tests. Pro-convulsant and anticholinergic effects were also evaluated. EHFAC presented anxiolytic-like effect on the elevated plus-maze, which was partially reversed by flumazenil. A similar effect was observed with CA. In the forced swimming test, EHFAC and CA reduced the immobility time of mice; such effect was potentiated when EHFAC or CA were associated with imipramine, bupropion and fluoxetine. The antidepressant-like effect was reinforced as EHFAC partially reversed the reserpine-induced akinesia. In addition, a pre-treatment with EHFAC and CA did not decrease the latency to 1st seizure of animals that received a sub-convulsive dose of PTZ, nor reduced the intensity of oxotremorine-induced tremors. Taken together, the results indicate that EHFAC and CA have anxiolytic and antidepressant-like effects, which involve important neurotransmitter systems, such as GABAergic and monoaminergic ones, being devoid of side effects, commonly associated with classical psychotropic drugs.

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