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Impact of cirrhosis in patients undergoing laparoscopic liver resection in a nationwide multicentre survey

2020; Oxford University Press; Volume: 107; Issue: 3 Linguagem: Inglês

10.1002/bjs.11406

1365-2168

Christian Hobeika, David Fuks, François Cauchy, Claire Goumard, Olivier Soubrane, Brice Gayet, Ephrem Salamé, Daniel Cherqui, Éric Vibert, Olivier Scatton, Takeo Nomi, Nassima Oudafal, Takayuki Kawai, Shohei Komatsu, Shinya Okumura, Niccolò Petrucciani, Alexis Laurent, Petru Bucur, Louise Barbier, B. Tréchot, Julio Núñez, Michele Tedeschi, M.-A. Allard, Nicolas Golse, Oriana Ciacio, Gabriella Pittau, António Sá Cunha, R. Adam, Christophe Laurent, L. Chiche, P. Léourier, Lionel Rebibo, Jean‐Marc Regimbeau, Laura Ferrè, Régis Souche, Jean Chauvat, J Fabre, François Jehaes, Kayvan Mohkam, Mickaël Lesurtel, Christian Ducerf, J-Y Mabrut, T. Hor, François Paye, Pierre Balladur, Bertrand Suc, Fabrice Muscari, Guillaume Y. Millet, Mehdi El Amrani, Christine K. Ratajczak, Katia Lécolle, Emmanuel Boleslawski, Stéphanie Truant, F.R. Pruvot, A-R Kianmanesh, Tatiana Codjia, Lilian Schwarz, Édouard Girard, J. Abba, Christian Létoublon, Mircea Chirica, Abenavoli Carmelo, Charles Vanbrugghe, Zineb Cherkaoui, Xavier Unterteiner, Riccardo Memeo, Patrick Pessaux, Emmanuel Buc, Émilie Lermite, J. Barbieux, M. Bougard, Ugo Marchèse, Jacques Ewald, Olivier Turini, Alexandre Thobie, Benjamin Menahem, A. Mulliri, Jean Lubrano, J. Zemour, H. Fagot, Guillaume Passot, Émilie Grégoire, Jean Hardwigsen, Y.P. Le Treut, D Patrice,

Liver Disease and Transplantation

Abstract Background The aim was to analyse the impact of cirrhosis on short-term outcomes after laparoscopic liver resection (LLR) in a multicentre national cohort study. Methods This retrospective study included all patients undergoing LLR in 27 centres between 2000 and 2017. Cirrhosis was defined as F4 fibrosis on pathological examination. Short-term outcomes of patients with and without liver cirrhosis were compared after propensity score matching by centre volume, demographic and tumour characteristics, and extent of resection. Results Among 3150 patients included, LLR was performed in 774 patients with (24·6 per cent) and 2376 (75·4 per cent) without cirrhosis. Severe complication and mortality rates in patients with cirrhosis were 10·6 and 2·6 per cent respectively. Posthepatectomy liver failure (PHLF) developed in 3·6 per cent of patients with cirrhosis and was the major cause of death (11 of 20 patients). After matching, patients with cirrhosis tended to have higher rates of severe complications (odds ratio (OR) 1·74, 95 per cent c.i. 0·92 to 3·41; P = 0·096) and PHLF (OR 7·13, 0·91 to 323·10; P = 0·068) than those without cirrhosis. They also had a higher risk of death (OR 5·13, 1·08 to 48·61; P = 0·039). Rates of cardiorespiratory complications (P = 0·338), bile leakage (P = 0·286) and reoperation (P = 0·352) were similar in the two groups. Patients with cirrhosis had a longer hospital stay than those without (11 versus 8 days; P = 0·018). Centre expertise was an independent protective factor against PHLF in patients with cirrhosis (OR 0·33, 0·14 to 0·76; P = 0·010). Conclusion Underlying cirrhosis remains an independent risk factor for impaired outcomes in patients undergoing LLR, even in expert centres.