Improving the Anti-inflammatory Response via Gold Nanoparticle Vectorization of CO-Releasing Molecules
2020; American Chemical Society; Volume: 6; Issue: 2 Linguagem: Inglês
10.1021/acsbiomaterials.9b01936
ISSN2373-9878
AutoresAlexandra R. Fernandes, Inês Mendonça-Martins, Marino F. A. Santos, Luís R. Raposo, Rita Mendes, Joana Marques, Carlos C. Romão, Maria João Romão, Teresa Santos‐Silva, Pedro V. Baptista,
Tópico(s)Cannabis and Cannabinoid Research
ResumoCO-releasing molecules (CORMs) have been widely studied for their anti-inflammatory, antiapoptotic, and antiproliferative effects. CORM-3 is a water-soluble Ru-based metal carbonyl complex, which metallates serum proteins and readily releases CO in biological media. In this work, we evaluated the anti-inflammatory and wound-healing effects of gold nanoparticles–CORM-3 conjugates, AuNPs@PEG@BSA·Ru(CO)x, exploring its use as an efficient CO carrier. Our results suggest that the nanoformulation was capable of inducing a more pronounced cell effect, at the anti-inflammatory level and a faster tissue repair, probably derived from a rapid cell uptake of the nanoformulation that results in the increase of CO inside the cell.
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