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BIBTEX RIS

Prosopis juliflora as a new cosmetic ingredient: Development and clinical evaluation of a bioactive moisturizing and anti-aging innovative solid core

2020; Elsevier BV; Volume: 233; Linguagem: Inglês

10.1016/j.carbpol.2020.115854

1879-1344

Gabriel A.B. Damasceno, Stella Maria Andrade Gomes Barreto, Fernanda Priscila Santos Reginaldo, Augusto Lopes Souto, Marília Medeiros Fernandes de Negreiros, Rony Lucas Silva Viana, Talita K. B. Pinto, Cláudia Cecílio Daher, Jean A.A. Silva-Filho, Rafael A.O. Moura, Milena A. Silva, Walteçá Louis Lima da Silveira, Andreza A. Medeiros, Elissa Arantes Ostrosky, Lourena Mafra Veríssimo, Guilherme L. Sassaki, Patrícia Santos Lopes, Valéria Soraya Farias Sales, Hugo Alexandre Oliveira Rocha, Alberto José Cavalheiro, Raquel Brandt Giordani, Márcio Ferrari,

Microencapsulation and Drying Processes

Prosopis juliflora is an invasive plant distributed throughout the world and presents metabolites of interest for cosmetology. The aim of this work was to develop a new polysaccharide-based ingredient from P. juliflora and analyze its application in a solid core formulation that upon contact with water instantly forms a gel to improve moisturizing and anti-aging skin properties. Purified extracts by gel chromatography were characterized by NMR and LC-DAD-MS-MS. The in vitro and in vivo safety, antioxidant activity, formulation development and clinical evaluation were performed. The extract was characterized as containing an α-glucan and phenolics. It was non-cytotoxic, non-phototoxic and no skin reactions were observed in vivo. Antioxidant activity were present through different mechanisms. Clinical evaluation reinforced the potential of P. juliflora in skin hydration and microrelief improvement. This innovative form proved to be a prototype of a new product and the first study of an α-glucan as a cosmetic ingredient.