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Does acute peripheral trauma contribute to idiopathic adult-onset dystonia?

2020; Elsevier BV; Volume: 71; Linguagem: Inglês

10.1016/j.parkreldis.2020.01.002

1873-5126

Giovanni Defazio, Giovanni Fabbrini, Roberto Erro, Alberto Albanese, Paolo Barone, Maurizio Zibetti, Marcello Esposito, Roberta Pellicciari, Laura Avanzino, Francesco Bono, Roberto Eleopra, Laura Bertolasi, Maria Concetta Altavista, Maria Sofia Cotelli, Roberto Ceravolo, Cesa Scaglione, Anna Rita Bentivoglio, Giovanni Cossu, Mario Coletti Moja, Paolo Girlanda, Salvatore Misceo, Antonio Pisani, Marcello Mario Mascia, Tommaso Ercoli, Michèle Tinazzi, Luca Maderna, Brigida Minafra, Luca Magistrelli, Marcello Romano, Marco Aguggia, Nicola Tambasco, Anna Castagna, Daniela Cassano, Alfredo Berardelli, Gina Ferrazzano, Stefania Lalli, Francesco Silvestre, Fiore Manganelli, Francesca Di Biasio, Roberta Marchese, Giulio Demonte, Domenico Santangelo, Grazia Devigili, Valentina Durastanti, Marinella Turla, Sonia Mazzucchi, Martina Petracca, Valentina Oppo, Pierangelo Barbero, Francesca Morgante, Giulia Di Lazzaro, Giovanna Squintani, Nicola Modugno,

Parkinson's Disease Mechanisms and Treatments

Background Acute peripheral trauma is a controversial risk factor for idiopathic dystonia. Materials and methods We retrospectively analyzed data from the Italian Dystonia Registry regarding the occurrence of acute peripheral trauma severe enough to require medical attention in 1382 patients with adult-onset idiopathic dystonia and 200 patients with acquired adult-onset dystonia. Results Patients with idiopathic and acquired dystonia showed a similar burden of peripheral trauma in terms of the number of patients who experienced trauma (115/1382 vs. 12/200, p = 0.3) and the overall number of injuries (145 for the 1382 idiopathic patients and 14 for the 200 patients with secondary dystonia, p = 0.2). Most traumas occurred before the onset of idiopathic or secondary dystonia but only a minority of such injuries (14 in the idiopathic group, 2 in the acquired group, p = 0.6) affected the same body part as that affected by dystonia. In the idiopathic group, the elapsed time between trauma and dystonia onset was 8.1 ± 9.2 years; only six of the 145 traumas (4.1%) experienced by 5/1382 idiopathic patients (0.36%) occurred one year or less before dystonia onset; in the acquired dystonia group, the two patients experienced prior trauma to the dystonic body part 5 and 6 years before dystonia development. Discussion and conclusion Our data suggest that the contribution of peripheral acute trauma to idiopathic dystonia is negligible, if anything, and likely involves only a small subset of patients.