Portal de Periódicos da CAPES

NAD+ homeostasis in health and disease

2020; Nature Portfolio; Volume: 2; Issue: 1 Linguagem: Inglês

10.1038/s42255-019-0161-5

2522-5812

Elena Katsyuba, Mario Romani, Dina Hofer, Johan Auwerx,

PARP inhibition in cancer therapy

The conceptual evolution of nicotinamide adenine dinucleotide (NAD+) from being seen as a simple metabolic cofactor to a pivotal cosubstrate for proteins regulating metabolism and longevity, including the sirtuin family of protein deacylases, has led to a new wave of scientific interest in NAD+. NAD+ levels decline during ageing, and alterations in NAD+ homeostasis can be found in virtually all age-related diseases, including neurodegeneration, diabetes and cancer. In preclinical settings, various strategies to increase NAD+ levels have shown beneficial effects, thus starting a competitive race to discover marketable NAD+ boosters to improve healthspan and lifespan. Here, we review the basics of NAD+ biochemistry and metabolism, and its roles in health and disease, and we discuss current challenges and the future translational potential of NAD+ research. Auwerx and colleagues review the fundamentals of NAD+ metabolism and its roles in organismal health and disease.