Portal de Periódicos da CAPES

Precursor lesions of vulvar squamous cell carcinoma – histology and biomarkers: A systematic review

2020; Elsevier BV; Volume: 147; Linguagem: Inglês

10.1016/j.critrevonc.2020.102866

1879-0461

Shatavisha Dasgupta, Patricia C. Ewing‐Graham, Sigrid Swagemakers, Peter J. van der Spek, Helena C. van Doorn, Vincent Noordhoek Hegt, Senada Koljenović, Folkert J. van Kemenade,

Molecular Biology Techniques and Applications

The precursor lesion of vulvar squamous cell carcinoma (VSCC), namely vulvar intraepithelial neoplasia (VIN), is classified as: human papillomavirus (HPV)-related high grade squamous intraepithelial lesion (HSIL), and HPV-independent differentiated VIN (dVIN). Traditionally, histology and immunohistochemistry (IHC) have been the basis of diagnosis and classification of VIN. HSIL shows conspicuous histological atypia, and positivity on p16-IHC, whereas dVIN shows less obvious histological atypia, and overexpression or null-pattern on p53-IHC. For both types of VIN, other diagnostic immunohistochemical markers have also been evaluated. Molecular characterization of VIN has been attempted in few recent studies, and novel genotypic subtypes of HPV-independent VSCC and VIN have been identified. This systematic review appraises the VSCC precursors identified so far, focusing on histology and biomarkers (immunohistochemical and molecular). To gain further insights into the carcinogenesis and to identify additional potential biomarkers, gene expression omnibus (GEO) datasets on VSCC were analyzed; the results are presented.