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Bifunctional RNA‐Targeting Deoxyribozyme Nanodevice as a Potential Theranostic Agent

2020; Wiley; Volume: 26; Issue: 16 Linguagem: Inglês

10.1002/chem.201905528

1521-3765

Aleksandr A. Spelkov, Ekaterina A. Goncharova, Artemii Savin, Dmitry M. Kolpashchikov,

Bacteriophages and microbial interactions

Abstract Theranostic approaches rely on simultaneous diagnostic of a disease and its therapy. Here, we designed a DNA nanodevice, which can simultaneously report the presence of a specific RNA target through an increase in fluorescence and cleave it. High selectivity of RNA target recognition under near physiological conditions was achieved. The proposed approach can become a basis for the design of DNA nanomachines and robots for diagnostics and therapy of viral infections, cancer, and genetic disorders.