Produção Nacional
Revisado por pares
Chemical profiling of Curatella americana Linn leaves by UPLC-HRMS and its wound healing activity in mice
2020; Public Library of Science; Volume: 15; Issue: 1 Linguagem: Inglês
10.1371/journal.pone.0225514
ISSN1932-6203
AutoresMayara Amoras Teles Fujishima, Dayse Maria da Cunha Sá, Carolina Miranda de Sousa Lima, José Bittencourt, Washington Luiz Assunção Pereira, Abraão de Jesus Barbosa Muribeca, Consuelo Yumiko Yoshioka e Silva, Milton Silva, Francisco Fábio Oliveira de Sousa, Cleydson B. R. Santos, Jocivânia Oliveira da Silva,
Tópico(s)Phytochemistry Medicinal Plant Applications
ResumoBased on ethnopharmacological studies, a lot of plants, as well as its compounds, have been investigated for the potential use as wound healing agents. In Brazil, Curatella americana is traditionally used by local people to treat wounds, ulcers and inflammations. However, to the best of our knowledge, its traditional use in the treatment of wounds has not been validated by a scientific study. Here, some compounds, many of them flavonoids, were identified in the hydroethanolic extract from the leaves of C. americana (HECA) by LC-HRMS and LC-MS/MS. Besides that, solutions containing different concentrations of HECA and a gel produced with this extract were evaluated for its antimicrobial, coagulant and wound healing activities on an excision mouse wound model as well as its acute dermal safety. A total of thirteen compounds were identified in HECA, mainly quercetin, kaempferol and glucoside derivatives of both, besides catechin and epicatechin known as wound healing agents. The group treated with 1% of HECA exhibited highest wound healing activity and best rate of wound contraction confirmed by histopathology results. The present study provides scientific evidence of, this extract (HECA) possess remarkable wound healing activity, thereby, supporting the traditional use.
Referência(s)