Produção Nacional
Revisado por pares
Anxiety-like behavior induced by salicylate depends on age and can be prevented by a single dose of 5-MeO-DMT
2020; Elsevier BV; Volume: 326; Linguagem: Inglês
10.1016/j.expneurol.2020.113175
ISSN1090-2430
AutoresJéssica Winne, Barbara Ciralli Boerner, T Malfatti, Elis Brisa, Jhulimar G. Doerl, Ingrid Nogueira, Katarina E. Leão, Richardson N. Leão,
Tópico(s)Psychedelics and Drug Studies
ResumoSalicylate intoxication is a cause of tinnitus and comorbidly associated with anxiety in humans. In a previous work, we showed that salicylate induces anxiety-like behavior and hippocampal type 2 theta oscillations (theta2) in mice. Here we investigate if the anxiogenic effect of salicylate is dependent on age and previous tinnitus experience. We also tested whether a single dose of DMT can prevent this effect. Using microwire electrode arrays, we recorded local field potential in young (4–5- month-old) and old (11–13-month-old) mice to study the electrophysiological effect of tinnitus in the ventral hippocampus (vHipp) and medial prefrontal cortex (mPFC) in an open field arena and elevated plus maze 1 h after salicylate (300 mg/kg) injection. We found that anxiety-like behavior and increase in theta2 oscillations (4–6 Hz), following salicylate pre-treatment, only occurs in young (normal hearing) mice. We also show that theta2 and slow gamma oscillations increase in the vHipp and mPFC in a complementary manner during anxiety tests in the presence of salicylate. Finally, we show that pre-treating mice with a single dose of the hallucinogenic 5-MeO-DMT prevents anxiety-like behavior and the increase in theta2 and slow gamma oscillations after salicylate injection in normal hearing young mice. This work further support the hypothesis that anxiety-like behavior after salicylate injection is triggered by tinnitus and require normal hearing. Moreover, our results show that hallucinogenic compounds can be effective in treating tinnitus-related anxiety.
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