Portal de Periódicos da CAPES

Artigo Produção Nacional Revisado por pares

BIBTEX RIS

Effect of Cell Therapy with Osteoblasts Differentiated from Bone Marrow or Adipose Tissue Stromal Cells on Bone Repair

2019; Future Medicine; Volume: 14; Issue: 12 Linguagem: Inglês

10.2217/rme-2019-0036

1746-076X

Gileade Pereira Freitas, Helena Bacha Lopes, Alann Thaffarell Portilho Souza, Paula Gabriela Faciola Pessôa de Oliveira, Adriana Luisa Gonçalves Almeida, Paulo G. Coelho, Fernanda Ursoli Ferreira, Dimas Tadeu Covas, Márcio Mateus Beloti, Adalberto Luiz Rosa,

Bone fractures and treatments

Aim: The aim of this study was to investigate the effect of local injection of osteoblasts differentiated from bone marrow (BM-OB) or adipose tissue (AT-OB) mesenchymal stromal cells on bone tissue formation. Materials & methods: Defects were created in rat calvaria and injected with BM-OB or AT-OB and phosphate-buffered saline without cells were injected as control. Bone formation was evaluated 4 weeks postinjection. Results: Injection of BM-OB or AT-OB resulted in higher bone formation than that obtained with control. The bone tissue induced by cell injections exhibited similar mechanical properties as those of pristine calvarial bone, and its molecular cues suggested the occurrence of a remodeling process. Conclusion: Results of this study demonstrated that cell therapy with osteoblasts induced significant bone formation that exhibited the same quality as that of pre-existent bone.