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Protective effect of vitamin C on chronic carbamazepine-induced reproductive toxicity in male wistar rats

2020; Elsevier BV; Volume: 7; Linguagem: Inglês

10.1016/j.toxrep.2020.01.017

2214-7500

Ganiu Jimoh Akorede, Suleiman Folorusho Ambali, Mikail Garba Hudu, Aisha Omobolanle Olatunji, Muftau Shittu, Abdulfatai Aremu, Afisu Basiru, K. T. Biobaku, Akeem Olayiwola Ahmed, S. A. Ameen,

Pharmacological Effects and Toxicity Studies

The aim of this study was to evaluate the protective effect of vitamin C on chronic carbamazepine-induced reproductive toxicity in male Wistar rats. Four groups of 10 rats were respectively exposed to distilled water (2 ml/kg), vitamin C (100 mg/kg), carbamazepine (20 mg/kg) and vitamin C followed by CBZ, after 30 min.. The regimens were given by gavage once daily for 15 weeks. The pituitary glands and testicular tissues were assayed for oxidative stress parameters, sperm characteristics, relative weight and histological changes. Sera samples were also assayed for concentration of sex hormones. The results showed that treatment with vitamin C protected against the alteration in parameters measuring oxidative changes, sex hormones, sperm characteristics, relative pituitary and testicular weight and histological changes. The study concluded that protection against CBZ-induced alteration in reproductive parameters by vitamin C was partly due to its antioxidant effect.