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Comparison of the Nancy Index With Continuous Geboes Score: Histological Remission and Response in Ulcerative Colitis

2020; Oxford University Press; Volume: 14; Issue: 7 Linguagem: Inglês

10.1093/ecco-jcc/jjaa010

1876-4479

Fernando Magro, Joanne Lopes, Paula Borralho, Cláudia Camila Dias, Joana Afonso, Paula Ministro, Mafalda Santiago, Karel Geboes, Fátima Carneiro, Susana Lopes, Rosa Coelho, José Cotter, Francisca Dias de Castro, Helena Tavares de Sousa, Marta Salgado, Patrícia Andrade, Ana Vieira, Pedro Figueiredo, Paulo Caldeira, A Sousa, Maria Antónia Duarte, Filipa Ávila, João S. Silva, Joana Moleiro, Sofia Mendes, Sílvia Giestas, Paula Sousa, Raquel Gonçalves, Bruno Gonçalves, Ana Maria Oliveira, Cristina Chagas,

Autoimmune and Inflammatory Disorders

Evidence has been supporting that histological activity of ulcerative colitis [UC] has relevance for the prediction of clinical outcomes in UC patients, such as clinical relapse. In this study, we aimed to compare two histological indexes-the continuous Geboes score [GS] and the Nancy index [NI] -regarding their definitions of histological remission and response, and to determine the ability of faecal calprotectin [FC] levels to discriminate between these histological statuses according to the NI.A large cohort of UC patients [N = 422] who were previously enrolled in other studies was analysed.GS and NI were shown to be strongly correlated [correlation coefficient: 0.882, p <0.001], indicating high accordance in the classification of patients as having/not having histological remission and response. FC levels moderately correlated with NI regarding these histological statuses [correlation coefficient: 0.481, p 0 {area under the curve (AUC) 0.667 (95% confidence interval [CI] 0.609-0.724)}, and were good predictors of the absence of histological response defined by NI >1 (AUC 0.825 [95% CI 0.777-0.872]). The optimal FC cut-offs determined to predict the NI-defined histological remission and response were 91 μg/g and 106 μg/g, when maximising the negative predictive value [NPV].Due to the higher applicability of the NI, this study encourages the systematic use of this histological index to assess histological remission and response in UC patients.