Portal de Periódicos da CAPES

Artigo Produção Nacional Revisado por pares

BIBTEX RIS

Flow-through amperometric determination of ampicillin using a copper electrode in a batch injection analysis system

2020; Elsevier BV; Volume: 155; Linguagem: Inglês

10.1016/j.measurement.2020.107516

1873-412X

William Barros Veloso, Geyse Adriana Corrêa Ribeiro, Cláudia Quintino da Rocha, Auro Atsushi Tanaka, Iranaldo Santos da Silva, Luiza Maria Ferreira Dantas,

Antibiotics Pharmacokinetics and Efficacy

This paper presents, for the first time, an amperometric electroanalytical method for ampicillin determination using a copper electrode in a batch injection analysis (BIA) system. Initial voltammetric measurements were performed to establish the working potential in the amperometric assays and to optimize parameters such as the supporting electrolyte and the pH of the medium. The method was shown to be precise (RSD = 3.5%, n = 18), reliable (confirmed by an application using a drug sample), sensitive (LOD = 7.11 μmol L−1; LOQ = 23.7 μmol L−1), and fast (86 injections h−1). The proposed method was successfully applied for the determination of ampicillin in commercial drug samples. The results were compared with those obtained using HPLC-UV/Vis and UV–Vis spectrophotometry. There were no significant differences, indicating that the new technique could be used in routine analyses.