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Isolation of Angola-like Marburg virus from Egyptian rousette bats from West Africa

2020; Nature Portfolio; Volume: 11; Issue: 1 Linguagem: Inglês

10.1038/s41467-020-14327-8

2041-1723

Brian R. Amman, Brian H. Bird, Ibrahim A. Bakarr, James Bangura, Amy J. Schuh, Jonathan Johnny, Tara K. Sealy, Immah Conteh, Alusine H. Koroma, Ibrahim K Foday, Emmanuel Amara, Abdulai Bangura, Aiah A. Gbakima, Alexandre Tremeau‐Bravard, Manjunatha N. Belaganahalli, Jasjeet Dhanota, Andrew Chow, Victoria Ontiveros, Alexandra A. Gibson, Joseph A Turay, Ketan Patel, James Graziano, Camilla Bangura, Emmanuel S. Kamanda, Augustus Osborne, Emmanuel Saidu, Jonathan A. Musa, Doris F. Bangura, Samuel Maxwell Tom Williams, Richard Wadsworth, Mohamed Turay, Lavalie Edwin, Vanessa Mereweather-Thompson, Dickson Kargbo, Fatmata V. Bairoh, Marilyn C. Kanu, Willie Robert, Victor Lungai, Raoul Emeric Guetiya Wadoum, Moinya Coomber, Osman T. Kanu, Amara Jambai, Sorie Mohamed Kamara, Céline H. Taboy, Tushar Singh, Jonna A. K. Mazet, Stuart T. Nichol, Tracey Goldstein, Jonathan S. Towner, Aiah Lebbie,

COVID-19 epidemiological studies

Abstract Marburg virus (MARV) causes sporadic outbreaks of severe Marburg virus disease (MVD). Most MVD outbreaks originated in East Africa and field studies in East Africa, South Africa, Zambia, and Gabon identified the Egyptian rousette bat (ERB; Rousettus aegyptiacus ) as a natural reservoir. However, the largest recorded MVD outbreak with the highest case–fatality ratio happened in 2005 in Angola, where direct spillover from bats was not shown. Here, collaborative studies by the Centers for Disease Control and Prevention, Njala University, University of California, Davis USAID-PREDICT, and the University of Makeni identify MARV circulating in ERBs in Sierra Leone. PCR, antibody and virus isolation data from 1755 bats of 42 species shows active MARV infection in approximately 2.5% of ERBs. Phylogenetic analysis identifies MARVs that are similar to the Angola strain. These results provide evidence of MARV circulation in West Africa and demonstrate the value of pathogen surveillance to identify previously undetected threats.