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Common, intermediate and well‐documented HLA alleles in world populations: CIWD version 3.0.0

2020; Wiley; Volume: 95; Issue: 6 Linguagem: Inglês

10.1111/tan.13811

2059-2310

Carolyn Katovich Hurley, Jane Kempenich, Kim Wadsworth, Jürgen Sauter, Jan A. Hofmann, Daniel Schefzyk, Alexander H. Schmidt, Pablo Galarza, M.B. Rodrı́guez Cardozo, Małgorzata Dudkiewicz, Lucie Houdová, Pavel Jindra, Betina Sørensen, Latha Jagannathan, Ankit Mathur, Tiina Linjama, Tigran Torosian, Rafi Freudenberger, Anastasios Manolis, John Mavrommatis, Nezih Cereb, Sigal Manor, Nira Shriki, Nicoletta Sacchi, Reem Ameen, Raewyn Fisher, H. Dunckley, Irene Andersen, Ahmed Alaskar, Mohsen Alzahrani, Ali H. Hajeer, Dunia Jawdat, Grazia Nicoloso, Pawinee Kupatawintu, Louise Cho, Ashminder Kaur, Mats Bengtsson, Jason Dehn,

Renal Transplantation Outcomes and Treatments

A catalog of common, intermediate and well‐documented (CIWD) HLA‐A, ‐B, ‐C, ‐DRB1, ‐DRB3, ‐DRB4, ‐DRB5, ‐DQB1 and ‐DPB1 alleles has been compiled from over 8 million individuals using data from 20 unrelated hematopoietic stem cell volunteer donor registries. Individuals are divided into seven geographic/ancestral/ethnic groups and data are summarized for each group and for the total population. P (two‐field) and G group assignments are divided into one of four frequency categories: common (≥1 in 10 000), intermediate (≥1 in 100 000), well‐documented (≥5 occurrences) or not‐CIWD. Overall 26% of alleles in IPD‐IMGT/HLA version 3.31.0 at P group resolution fall into the three CIWD categories. The two‐field catalog includes 18% (n = 545) common, 17% (n = 513) intermediate, and 65% (n = 1997) well‐documented alleles. Full‐field allele frequency data are provided but are limited in value by the variations in resolution used by the registries. A recommended CIWD list is based on the most frequent category in the total or any of the seven geographic/ancestral/ethnic groups. Data are also provided so users can compile a catalog specific to the population groups that they serve. Comparisons are made to three previous CWD reports representing more limited population groups. This catalog, CIWD version 3.0.0, is a step closer to the collection of global HLA frequencies and to a clearer view of HLA diversity in the human population as a whole.