Produção Nacional
Revisado por pares
Phenylamino-pyrimidine (PAP) Privileged Structure: Synthesis and Medicinal Applications
2020; Bentham Science Publishers; Volume: 20; Issue: 3 Linguagem: Inglês
10.2174/1568026620666200124094949
ISSN1873-4294
AutoresLuiz Cláudio Ferreira Pimentel, Anna C. Cunha, Lucas Villas Bôas Hoelz, Henayle Fernandes Canzian, Débora Inácio Leite, Núbia Boechat, Mônica M. Bastos,
Tópico(s)Synthesis and Characterization of Heterocyclic Compounds
ResumoThe phenylamino-pyrimidine (PAP) nucleus has been demonstrated to be useful for the development of new drugs and is present in a wide variety of antiretroviral agents and tyrosine kinase inhibitors (TKIs). This review aims to evaluate the application of PAP derivatives in drugs and other bioactive compounds. It was concluded that PAP derivatives are still worth exploring, as they may provide highly competitive ATP TKI’s with nano/picomolar activity.
Referência(s)