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BIBTEX RIS

Association between Single Nucleotide Polymorphisms and Glioma Risk: A Systematic Literature Review

2020; Taylor & Francis; Volume: 38; Issue: 3 Linguagem: Inglês

10.1080/07357907.2020.1719502

1532-4192

Cléciton Braga Tavares, Francisca das Chagas Sheyla Almeida Gomes Braga, Emerson Brandão Sousa, José Nazareno Pearce de Oliveira Brito, Mariella de Almeida Melo, Viriato Campelo, Fidelis Manes Neto, Ricardo Araújo, Iruena Moraes Kessler, Leonardo de Moura Sousa Júnior, Luís Carlos Carvalho Filho, Yousef Qathaf Aguiar, Pedro Vitor Lopes‐Costa, Benedito Borges da Silva,

Epigenetics and DNA Methylation

This study aimed to determine the main single nucleotide polymorphisms (SNPs) that are associated with an increased or decreased risk of glioma development in healthy individuals. We conducted a systematic review of the articles published in English on the PUBMED database between January 2008 and December 2017. Our search resulted in a total of 743 articles; however, only 56 were included in this review. A total of 148 polymorphisms were found, which involved 64 different genes. The polymorphisms that were most associated with an increased risk of glioma development were polymorphic variants rs179782, rs13181, and rs3791679 of the genes XRCC1, ERCC2, and EFEMP1, respectively.