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BIBTEX RIS

Global frequency and distribution of head and neck cancer in pediatrics, a systematic review

2020; Elsevier BV; Volume: 148; Linguagem: Inglês

10.1016/j.critrevonc.2020.102892

1879-0461

Lady Paola Aristizábal Arboleda, Regina Maria Holanda de Mendonça, Eliana Elisa Muñoz López, Anna Luíza Damaceno Araújo, Natália Rangel Palmier, Mariana de Pauli Paglioni, Jéssica Montenegro Fonsêca, Iva Loureiro Hoffmann, Izilda Aparecida Cardinalli, Aline Lauda Freitas Chaves, Saray Aranda‐Romo, Thaís Bianca Brandão, Márcio Ajudarte Lopes, Ana Carolina Prado Ribeiro, Cristhian Camilo Madrid Troconis, Alan Roger Santos‐Silva,

Cleft Lip and Palate Research

Incidence and mortality rates of childhood cancer represent a global public health issue, however, the worldwide prevalence of head and neck cancer in pediatric patients (HNCPP) is still unknown. Therefore, this study aimed to describe the frequency and distribution of HNCPP worldwide. A specific search strategy was performed using MEDLINE, Scopus, and EMBASE to include studies based on hospital records, national cancer registries, and pathology files. Studies quality was assessed using the risk of bias checklist of the Joanna Briggs Institute Critical Appraisal. Nineteen publications (15,970 cases) were included. Global frequency ranged from 0.25 % to 15 %. Male patients older than 10 years of age were most affected by lymphomas, followed by carcinomas and sarcomas. Non-Hodgkin lymphoma, Hodgkin lymphoma, rhabdomyosarcoma, thyroid carcinoma, and nasopharyngeal carcinoma were the main histopathological subtypes. Neck/lymph nodes were anatomical hotspots. This HNCPP global overview may guide secondary prevention strategies and future etiological studies.