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Nitric oxide biosynthesis during normal pregnancy and pregnancy complicated by preeclampsia

2017; Medical Association of Zenica-Doboj Canton; Volume: 14; Issue: 2 Linguagem: Inglês

10.17392/915-17

1840-2445

Jasmin Hodžić, Sebija Izetbegović, Bedrana Muračević, Rasim Iriškić, Hana Štimjanin Jović,

Pregnancy and Medication Impact

<p><strong>Aim <br /></strong>To investigate biosynthesis in nitric oxide (NO) during normal pregnancy and in pregnancies complicated by preeclampsia. <strong>Methods<br /></strong> This prospective cross-sectional study included 80 patients hospitalized at the Department of Women's Health, Neonatology and Perinatology Cantonal Hospital in Zenica. Serum NO concentration in 20 non-pregnant women, 40 healthy pregnant women and 20 pregnant women with preeclampsia aged 17-40 years were measured. The group of healthy pregnant women were divided into 4 subgroups by gestational age. For each woman with preeclampsia, a healthy pregnant control was matched for age, parity and gestational age. Serum NO concentrations were determined after reduction of nitrates to nitrites using the Griess reaction. <br /><strong>Results<br /></strong> NO concentrations during second trimester of pregnancy (37.2±1.7µM; p<0.05) and third trimester of pregnancy (40.9±2.8μM; p<0.05) were significantly higher in healthy pregnant women than in non-pregnant women (29.3±1.7μM). Serum NO concentrations were lower in preeclamptic women (30.7±1.8μM) compared to matched healthy pregnant women of the third and the late third trimester (35.1±2.2μM), without significant differences. Mean NO concentrations in pre-eclamptic women was positively correlated with systolic blood pressure (r=0.58; p<0.01), diastolic blood pressure (r=0.45; p<0.05), creatinine clearance (r=0.48; p<0.05), uric acid (r=0.49; p<0.05), and negatively correlated with platelet count (r=-0.57; p<0.05). <br /><strong>Conclusion<br /></strong> NO production was increased with gestational age during normal pregnancy and slightly decreased in preeclampsia suggesting that NO may modulate the cardiovascular changes during normal pregnancy and pregnancy complicated by preeclampsia.</p>