Typical and Atypical Hemolytic Uremic Syndrome in the Critically Ill
2020; Elsevier BV; Volume: 36; Issue: 2 Linguagem: Inglês
10.1016/j.ccc.2019.11.004
ISSN1557-8232
AutoresCarlos L. Manrique‐Caballero, Sadudee Peerapornratana, Cassandra L. Formeck, Gaspar Del Rio‐Pertuz, Hernando Gomez Danies, John A. Kellum,
Tópico(s)Blood groups and transfusion
ResumoHemolytic uremic syndrome is characterized by microangiopathic hemolytic anemia, thrombocytopenia, and acute kidney injury. Disseminated intravascular coagulation, thrombotic thrombocytopenic purpura, and hemolytic uremic syndrome have a similar clinical presentation. Diagnostic needs to be prompt to decrease mortality, because identifying the different disorders can help to tailor specific, effective therapies. However, diagnosis is challenging and morbidity and mortality remain high, especially in the critically ill population. Development of clinical prediction scores and rapid diagnostic tests for hemolytic uremic syndrome based on mechanistic knowledge are needed to facilitate early diagnosis and assign timely specific treatments to patients with hemolytic uremic syndrome variants.
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