SGLT2 Inhibitor–Induced Sympathoinhibition
2020; Elsevier BV; Volume: 5; Issue: 2 Linguagem: Inglês
10.1016/j.jacbts.2019.11.007
ISSN2452-302X
AutoresLakshini Y. Herat, Aaron L. Magno, Caroline Rudnicka, Jana Hricová, Revathy Carnagarin, Natalie C. Ward, Angélique Arcambal, Márcio Galindo Kiuchi, Geoffrey A. Head, Markus P. Schlaich, Vance B. Matthews,
Tópico(s)Nitric Oxide and Endothelin Effects
ResumoRecent clinical trial data suggest a cardiorenal protective effect of sodium glucose cotransporter 2 (SGLT2) inhibition. We demonstrate that chemical denervation in neurogenic hypertensive Schlager (BPH/2J) mice reduced blood pressure, improved glucose homeostasis, and reduced renal SGLT2 protein expression. Inhibition of SGLT2 prevented weight gain, reduced blood pressure, significantly reduced elevations of tyrosine hydroxylase and norepinephrine, and protects against endothelial dysfunction. These findings provide evidence for significant crosstalk between activation of the sympathetic nervous system and SGLT2 regulation and possible ancillary effects on endothelial function, which may contribute to the observed cardiorenal protective effects of SGLT2 inhibition.
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