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Animal Health Risk assessment of multiple chemicals in essential oils for farm animals

2020; European Food Safety Authority; Volume: 17; Issue: 1 Linguagem: Inglês

10.2903/sp.efsa.2020.en-1760

2397-8325

Jean Lou CM Dorne, Paola Manini, Christer Högstrand,

Insect Pheromone Research and Control

EFSA Supporting PublicationsVolume 17, Issue 1 1760E Technical reportOpen Access Animal Health Risk assessment of multiple chemicals in essential oils for farm animals European Food Safety Authority (EFSA), European Food Safety Authority (EFSA)Search for more papers by this authorJean Lou CM Dorne, Jean Lou CM DorneSearch for more papers by this authorPaola Manini, Paola ManiniSearch for more papers by this authorChrister Hogstrand, Christer HogstrandSearch for more papers by this author European Food Safety Authority (EFSA), European Food Safety Authority (EFSA)Search for more papers by this authorJean Lou CM Dorne, Jean Lou CM DorneSearch for more papers by this authorPaola Manini, Paola ManiniSearch for more papers by this authorChrister Hogstrand, Christer HogstrandSearch for more papers by this author First published: 30 January 2020 https://doi.org/10.2903/sp.efsa.2020.EN-1760Citations: 1 Requestor:EFSA Question number: EFSA-Q-2018-00670 AboutPDF ToolsExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Abstract This technical report implements the EFSA MIXTOX guidance document for animal health risk assessment of combined exposure to multiple chemicals in essential oilsusing whole mixture and component-based approaches (WMA and CBA).The harmonised step wise approaches from the MIXTOX guidance are applied to the problem formulation, exposure assessment, hazard assessment and risk characterisation using conservative scenarios, available data and tools. Options for the refinement of the CBA are proposed for the exposure assessment and hazard assessment (toxicity and toxicokinetic data and models) steps as well as for the application of risk characterisation methods.For exposure assessment, exposure metrics are derived for the whole mixture or for each component of the assessment groupusing the maximum proposed use levels of the essential oil in feedcombined with the feed consumption patterns corrected for body weight for each farm animal species. For hazard assessment, combined chronic toxicity on a species-specific basis requires data collection of reference points from chronic tolerance studies in each farm species or (sub)-chronic toxicity studies on test species. For the WMA, the chronic toxicity of the whole mixture is used and divided by uncertainty factors.For the component-based approach, the chronic toxicity for each substance in each assessment group is collected. For risk characterisation using WMA and CBA, a margin of exposure approach and a combined margin of exposure approach are applied respectively.Options for refining the approachesfor the component-based approach are proposedincluding the use ofspecific toxic effectsfor the grouping of chemicals as well as the use of toxicokinetic data and generic physiologically-based kinetic models for farm animal species. References EFSA (European Food Safety Authority), 2015. Editorial: Increasing robustness, transparency and openness of scientific assessments. EFSA Journal 2015; 13(3):e13031, 3pp. https://doi.org/10.2903/j.efsa.2015.e13031. 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