Artigo Acesso aberto

Injectable hydrogel-based drug delivery system for cartilage regeneration

2020; Elsevier BV; Volume: 110; Linguagem: Inglês

10.1016/j.msec.2020.110702

ISSN

1873-0191

Autores

Luis García‐Fernández, Marta Olmeda-Lozano, Lorena Benito-Garzón, Antonio Pérez-Caballer, Julio San Román, Blanca Vázquez‐Lasa,

Tópico(s)

Inflammatory mediators and NSAID effects

Resumo

• Osteoarthrosis is a chronic degenerative disease that constitutes a public health problem. • Semi-IPN hydrogels loaded with anti-inflammatory drugs are developed for drug delivery. • Degradation/release profile of the hydrogels is anti-inflammatory drug dependent. • Naproxen-loaded hydrogels avoid the progression of cartilage degeneration. • Dexamethasone-loaded hydrogels allow cartilage regeneration and avoid osteoarthrosis progression.

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