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MDR/XDR-TB management of patients and contacts: Challenges facing the new decade. The 2020 clinical update by the Global Tuberculosis Network

2020; Elsevier BV; Volume: 92; Linguagem: Inglês

10.1016/j.ijid.2020.01.042

1878-3511

Giovanni Battista Migliori, Simon Tiberi, Alimuddin Zumla, Eskild Petersen, Jeremiah Chakaya, Christian Wejse, Marcela Muñoz Torrico, Raquel Duarte, Jan‐Willem C. Alffenaar, H. Simon Schaaf, Ben J. Marais, Daniela María Cirillo, Riccardo Alagna, Adrián Rendón, Emanuele Pontali, Alberto Piubello, José Natal Figueroa, Gabriella Ferlazzo, Alberto L. García‐Basteiro, Rosella Centis, Dina Visca, Lia D’Ambrosio, Giovanni Sotgiu, T. Abu Arkub, Onno W. Akkerman, Alena Aleksa, Evgeny Belilovski, Enrique Bernal, F.–X. Blanc, Martin J. Boeree, Borisov Se, Judith Bruchfeld, Julen Cadiñanos, José A. Caminero, Anna Cristina Calçada Carvalho, José Joaquín Cebrián Gallardo, Charalampos, Edvardas Danila, Lina Davies Forsman, Justin T. Denholm, Keertan Dheda, Roland Diel, Saulius Diktanas, Claudia C. Dobler, Martin Enwerem, Susanna Esposito, Nancy Salinas, Filippov Av, Beatrice Formenti, José-María García-García, Delia Goletti, R. Gomez Rosso, Gina Gualano, Petros Isaakidis, Anna Kaluzhenina, S Koirala, Līga Kukša, Heinke Kunst, Y. Li, Cécile Magis-Escurra, Vinicio Manfrin, Selene Manga, K. Manika, Valentina Marchese, Elena Martínez Robles, А. O. Мaryandyshev, Alberto Matteelli, Alessandro Wasum Mariani, Jesica Mazza‐Stalder, Fernanda Carvalho de Queiroz Mello, Lourdes Milagros Mendoza, A. Mesi, Skaidrius Miliauskas, H. Mustafa Hamdan, Norbert Ndjeka, M. Nieto Marcos, T.H.M. Ottenhoff, Domingo Palmero, Fabrizio Palmieri, Apostolos Papavasileiou, M. C. Payen, Agostina Pontarelli, Margareth Pretti Dalcolmo, S. Quirós Fernandez, R. Romero, D. Rossato Silva, Adonis Pino Santos, Barbara Seaworth, М. В. Синицын, Alena Skrahina, Ivan Solovič, Antonio Spanevello, Marina Tadolini, Chelseah Denise H. Torres, Zarir Udwadia, Martin van den Boom, Grigory Volchenkov, Askar Yedilbayev, R. Zaleskis, J.-P. Zellweger,

Pneumonia and Respiratory Infections

The continuous flow of new research articles on MDR-TB diagnosis, treatment, prevention and rehabilitation requires frequent update of existing guidelines. This review is aimed at providing clinicians and public health staff with an updated and easy-to-consult document arising from consensus of Global Tuberculosis Network (GTN) experts. The core published documents and guidelines have been reviewed, including the recently published MDR-TB WHO rapid advice and ATS/CDC/ERS/IDSA guidelines. After a rapid review of epidemiology and risk factors, the clinical priorities on MDR-TB diagnosis (including whole genome sequencing and drug-susceptibility testing interpretations) and treatment (treatment design and management, TB in children) are discussed. Furthermore, the review comprehensively describes the latest information on contact tracing and LTBI management in MDR-TB contacts, while providing guidance on post-treatment functional evaluation and rehabilitation of TB sequelae, infection control and other public health priorities.