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Amyloid and Tau Pathology Associations With Personality Traits, Neuropsychiatric Symptoms, and Cognitive Lifestyle in the Preclinical Phases of Sporadic and Autosomal Dominant Alzheimer’s Disease

2020; Elsevier BV; Volume: 89; Issue: 8 Linguagem: Inglês

10.1016/j.biopsych.2020.01.023

1873-2402

Alexa Pichet Binette, Étienne Vachon‐Presseau, John C. Morris, Randall J. Bateman, Tammie L.S. Benzinger, D. Louis Collins, Judes Poirier, John C.S. Breitner, Sylvia Villeneuve, Ricardo Allegri, Fatima Amtashar, Randy Bateman, Tammie L.S. Benzinger, Sarah Berman, Courtney Bodge, Susan Brandon, William S. Brooks, Jill Buck, Virginia Buckles, Sochenda Chea, Jasmeer P. Chhatwal, Patricio Chrem, Helena C. Chui, Jake Cinco, Clifford Jack, Carlos Cruchaga, Mirelle D’Mello, Tamara Donahue, Jane Douglas, Noelia Edigo, Nilufer Erekin-Taner, Anne M. Fagan, Marty Farlow, Angela Farrar, Howard Feldman, Gigi Flynn, Nick C. Fox, Erin Franklin, Hisako Fujii, Cortaiga Gant, Samantha L. Gardener, Bernardino Ghetti, Alison Goate, Jill Goldman, Brian A. Gordon, Neill Graff-Radford, Julia Gray, Jenny Gurney, Jason Hassenstab, Mie Hirohara, David M. Holtzman, Russ C. Hornbeck, Siri Houeland DiBari, Takeshi Ikeuchi, Snežana Ikonomović, Gina Jerome, Mathias Jucker, Celeste M. Karch, Kensaku Kasuga, Takeshi Kawarabayashi, William E. Klunk, Robert A. Koeppe, Elke Kuder-Buletta, Christoph Laske, Jae‐Hong Lee, Johannes Levin, Daniel S. Marcus, Ralph N. Martins, Neal Scott Mason, Colin L. Masters, Denise Maue-Dreyfus, Eric McDade, Lucy Montoya, Hiroshi Mori, John C. Morris, Akem Nagamatsu, Katie Neimeyer, James M. Noble, Joanne Norton, Richard J. Perrin, Marc Raichle, John M. Ringman, Jee Hoon Roh, Stephen Salloway, Peter R. Schofield, Hiroyuki Shimada, Tomoyo Shiroto, Mikio Shoji, Wendy Sigurdson, Hamid R. Sohrabi, Paige Sparks, Kazushi Suzuki, Laura Swisher, Kevin Taddei, Jen C. Wang, Peter Wang, Mike Weiner, Mary Wolfsberger, Chengjie Xiong, Xu Xiong, Angela Tam, Anne Labonté, Alexa Pichet Binette, Anne-Marie Faubert, Axel Mathieu, Cécile Madjar, Charles Edouard Carrier, Christian Dansereau, Christina Kazazian, Claude Lepage, Cynthia Picard, David Maillet, Diane Michaud, Doris Couture, Doris Dea, A. Claudio Cuello, Alan Barkun, Alan C. Evans, Blandine Courcot, Christine L. Tardif, Clément Debacker, Clifford R. Jack, David Fontaine, David S. Knopman, Gerhard Maultaup, Jamie Near, Jeannie‐Marie Leoutsakos, Jean-Robert Maltais, Jason Brandt, Jens C. Pruessner, John C. Morris, John C.S. Breitner, Judes Poirier, Laksanun Cheewakriengkrai, Lisa Marie Munter, D. Louis Collins, M. Mallar Chakravarty, Mark A. Sager, Marina Dauar-Tedeschi, Mark J. Eisenberg, Natasha Rajah, Paul Aisen, Joanne Toussaint, Pedro Rosa‐Neto, Pierre Bellec, Penelope Kostopoulos, Pierre Étienne, Pierre N. Tariot, Pierre Orban, Reisa A. Sperling, Rick Hoge, Ronald G. Thomas, Serge Gauthier, Suzanne Craft, Sylvia Villeneuve, Thomas J. Montine, Vasavan Nair, Véronique D. Bohbot, Vinod Venugopalan, Vladimir Fonov, Yasser Ituria-Medina, Zaven S. Khachaturian, Eduard Teigner, Elena Anthal, Elsa Yu, Fabiola Ferdinand, Galina Pogossova, Ginette Mayrand, Guerda Duclair, Guylaine Gagné, Holly Newbold-Fox, Illana Leppert, Isabelle Vallée, Jacob W. Vogel, Jennifer Tremblay‐Mercier, Joanne Frenette, Josée Frappier, Justin Kat, Justin Miron, Karen Wan, Laura Mahar, Leopoldina Carmo, Louise Théroux, Mahsa Dadar, Marianne Dufour, Marie‐Élyse Lafaille‐Magnan, Melissa Appleby, Mélissa Savard, Miranda Tuwaig, Mirela Petkova, Pierre Rioux, Pierre‐François Meyer, Rana El-Khoury, Renee Gordon, Renuka Giles, Samir Das, Seqian Wang, Shirin Tabrizi, Sulantha Mathotaarachchi, Sylvie Dubuc, Tanya Lee, Thomas Beaudry, Valérie Gervais, Véronique Pagé, Julie Gonneaud, Gülebru Ayrancı, Tharick A. Pascoal, René Désautels, Fatiha Benbouhoud, Eunice Farah Saint-Fort, Sander C.J. Verfaillie, Sarah Farzin, Alyssa Salaciak, Stéphanie Tullo, Étienne Vachon‐Presseau, Leslie-Ann Daoust, Theresa Köbe, R. Nathan Spreng, Melissa McSweeney, Nathalie Nilsson, Morteza Pishnamazi, Christophe Bedetti,

Functional Brain Connectivity Studies

Background Major prevention trials for Alzheimer's disease (AD) are now focusing on multidomain lifestyle interventions. However, the exact combination of behavioral factors related to AD pathology remains unclear. In 2 cohorts of cognitively unimpaired individuals at risk of AD, we examined which combinations of personality traits, neuropsychiatric symptoms, and cognitive lifestyle (years of education or lifetime cognitive activity) related to the pathological hallmarks of AD, amyloid-β, and tau deposits. Methods A total of 115 older adults with a parental or multiple-sibling family history of sporadic AD (PREVENT-AD [PRe-symptomatic EValuation of Experimental or Novel Treatments for AD] cohort) underwent amyloid and tau positron emission tomography and answered several questionnaires related to behavioral attributes. Separately, we studied 117 mutation carriers from the DIAN (Dominant Inherited Alzheimer Network) study group cohort with amyloid positron emission tomography and behavioral data. Using partial least squares analysis, we identified latent variables relating amyloid or tau pathology with combinations of personality traits, neuropsychiatric symptoms, and cognitive lifestyle. Results In PREVENT-AD, lower neuroticism, neuropsychiatric burden, and higher education were associated with less amyloid deposition (p = .014). Lower neuroticism and neuropsychiatric features, along with higher measures of openness and extraversion, were related to less tau deposition (p = .006). In DIAN, lower neuropsychiatric burden and higher education were also associated with less amyloid (p = .005). The combination of these factors accounted for up to 14% of AD pathology. Conclusions In the preclinical phase of both sporadic and autosomal dominant AD, multiple behavioral features were associated with AD pathology. These results may suggest potential pathways by which multidomain interventions might help delay AD onset or progression.