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Genomic and Epidemiological Surveillance of Zika Virus in the Amazon Region

2020; Cell Press; Volume: 30; Issue: 7 Linguagem: Inglês

10.1016/j.celrep.2020.01.085

2639-1856

Marta Giovanetti, Nuno R. Faria, José Lourenço, Jaqueline Góes de Jesus, Joilson Xavier, Ingra Morales Claro, Moritz U. G. Kraemer, Vagner Fonseca, Simon Dellicour, Julien Thézé, Flavia da Silva Salles, Tiago Gräf, Paola Paz Silveira, Valdinete Alves do Nascimento, Victor Costa de Souza, Felipe Campos de Melo Iani, Emerson Augusto Castilho-Martins, Laura N. Cruz, Gabriel Luz Wallau, Allison Fabri, Flávia Mauad Levy, Joshua Quick, Vasco Azevedo, Renato Santana Aguiar, Túlio de Oliveira, Camila Bôtto de Menezes, Márcia da Costa Castilho, Tirza Matos Terra, Marineide Souza da Silva, Ana María Bispo de Filippis, André Luiz de Abreu, Wanderson Kleber de Oliveira, Júlio Croda, Carlos F. Campelo de Albuquerque, Márcio Roberto Teixeira Nunes, Éster Cerdeira Sabino, Nicholas J. Loman, Felipe Gomes Naveca, Oliver G. Pybus, Luíz Carlos Júnior Alcântara,

Virology and Viral Diseases

Zika virus (ZIKV) has caused an explosive epidemic linked to severe clinical outcomes in the Americas. As of June 2018, 4,929 ZIKV suspected infections and 46 congenital syndrome cases had been reported in Manaus, Amazonas, Brazil. Although Manaus is a key demographic hub in the Amazon region, little is known about the ZIKV epidemic there, in terms of both transmission and viral genetic diversity. Using portable virus genome sequencing, we generated 59 ZIKV genomes in Manaus. Phylogenetic analyses indicated multiple introductions of ZIKV from northeastern Brazil to Manaus. Spatial genomic analysis of virus movement among six areas in Manaus suggested that populous northern neighborhoods acted as sources of virus transmission to other neighborhoods. Our study revealed how the ZIKV epidemic was ignited and maintained within the largest urban metropolis in the Amazon. These results might contribute to improving the public health response to outbreaks in Brazil.