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Common Structural Patterns in the Maxicircle Divergent Region of Trypanosomatidae

2020; Multidisciplinary Digital Publishing Institute; Volume: 9; Issue: 2 Linguagem: Inglês

10.3390/pathogens9020100

2076-0817

Evgeny S. Gerasimov, Ksenia A. Zamyatnina, Nadezda S. Matveeva, Yulia A. Rudenskaya, Natalya Kraeva, Alexander Kolesnikov, Vyacheslav Yurchenko,

Insect symbiosis and bacterial influences

Maxicircles of all kinetoplastid flagellates are functional analogs of mitochondrial genome of other eukaryotes. They consist of two distinct parts, called the coding region and the divergent region (DR). The DR is composed of highly repetitive sequences and, as such, remains the least explored segment of a trypanosomatid genome. It is extremely difficult to sequence and assemble, that is why very few full length maxicircle sequences were available until now. Using PacBio data, we assembled 17 complete maxicircles from different species of trypanosomatids. Here we present their large-scale comparative analysis and describe common patterns of DR organization in trypanosomatids.