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Anthropometry, body shape in early-life and risk of premenopausal breast cancer among Latin American women: results from the PRECAMA study

2020; Nature Portfolio; Volume: 10; Issue: 1 Linguagem: Inglês

10.1038/s41598-020-59056-6

2045-2322

Mathilde His, Carine Biessy, Gabriela Torres-Mejı́a, Angélica Ángeles-Llerenas, Isabel Alvarado‐Cabrero, Gloria Inés Sánchez, Mauricio Borrero, Carolina Porras, Ana Cecilia Rodríguez, María Luisa Garmendia, Magali Olivier, Peggy L. Porter, Minggang Lin, Marc J. Gunter, Isabelle Romieu, Sabina Rinaldi, Jenny Tejeda, Édgar Navarro, Roberto Jaramillo, Yorlany Rodas Cortés, Alberto Angel, Carlos Andrés Ossa, William Arias, Gabriel Bedoya, Alicia Cock‐Rada, Carolina Echeverri, Fernando Herazo, Israel Díaz-Yúnez, Angel Hernández, Bernal Cortés, Paula González, Rebecca Ocampo, Diego Guillén, Leonor Moyano, José Luis Soto, Elizabeth Donato, Jamie Guenthoer, Thomas Donn, Kelly Wirtala, Hailey Loucks,

Birth, Development, and Health

Abstract Cumulating evidence in Caucasian women suggests a positive association between height and premenopausal breast cancer risk and a negative association with overall adiposity; however data from Latin America are scarce. We investigated the associations between excess adiposity, body shape evolution across life, and risk of premenopausal breast cancer among 406 cases (women aged 20–45) and 406 matched population-based controls from Chile, Colombia, Costa Rica, and Mexico. Negative associations between adult adiposity and breast cancer risk were observed in adjusted models (body mass index (BMI): Odds ratio (OR) per 1 kg/m 2 = 0.93; 95% confidence interval = 0.89–0.96; waist circumference (WC): OR per 10 cm = 0.81 (0.69–0.96); hip circumference (HC): OR per 10 cm = 0.80 (0.67–0.95)). Height and leg length were not associated with risk. In normal weight women (18.5 ≤ BMI < 25), women with central obesity (WC > 88 cm) had an increased risk compared to women with normal WC (OR = 3.60(1.47–8.79)). Residuals of WC over BMI showed positive associations when adjusted for BMI (OR per 10 cm = 1.38 (0.98–1.94)). Body shape at younger ages and body shape evolution were not associated with risk. No heterogeneity was observed by receptor status. In this population of Latin American premenopausal women, different fat distributions in adulthood were differentially associated with risk of breast cancer.