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The Evolution of Antimicrobial Resistance in Mexico During the Last Decade: Results from the INVIFAR Group

2020; Mary Ann Liebert, Inc.; Volume: 26; Issue: 11 Linguagem: Inglês

10.1089/mdr.2019.0354

1931-8448

Elvira Garza‐González, Rafael Franco‐Cendejas, Rayo Morfín‐Otero, Gabriela Echániz-Avilés, Fabián Rojas‐Larios, Paola Bocanegra‐Ibarias, Samantha Flores-Treviño, Alfredo Ponce‐de‐León, Eduardo Rodríguez-Noriega, Norma Alavez-Ramírez, Juan Pablo Mena-Ramírez, Joaquín Rincón-Zuno, María Guadalupe Fong-Camargo, Cecilia Teresita Morales-de-la-Peña, Carla Rocio Huerta-Baltazar, Luis Esaú López-Jácome, María Noemí Carnalla-Barajas, Araceli Soto‐Noguerón, Domingo Sánchez-Francia, David Moncada-Barrón, Edgar Ortíz‐Brizuela, Lourdes García-Mendoza, Oscar Alberto Newton-Sánchez, Elena Victoria Choy-Chang, Laura Karina Avilés-Benítez, Rafael Martínez Miranda, José Manuel Feliciano-Guzmán, Cynthia D. Peña-López, Carlos Antonio Couoh-May, Eduardo López-Gutiérrez, Mariana Gil-Veloz, Luis Carlos Armenta-Rodríguez, Marisol Manríquez-Reyes, Maricruz Gutierrez-Brito, Ismelda López-Ovilla, César Adame-Álvarez, Juan Manuel Barajas-Magallón, Efrén Aguirre-Burciaga, Adriana Mabel Coronado-Ramírez, Alina Aracely Rosales-García, Silvia Sida-Rodríguez, Rosa Elma Urbina-Rodríguez, Laura Isabel López-Moreno, Gloria Edith Juárez-Velázquez, Rebeca Thelma Martínez-Villarreal, Jorge Luis Canizales-Oviedo, Carlos Miguel Cetina-Umaña, María Magdalena Perez-Juárez, Arturo González-Moreno, Daniel Romero-Romero, Fidencio David Bello-Pazos, Gilberto Aguilar-Orozco, Nicolás Rogelio Eric Barlandas-Rendón, Joyarib Yanelli Maldonado-Anicacio, Alejandro Valadez-Quiroz, Adrián Camacho-Ortíz,

Pharmaceutical and Antibiotic Environmental Impacts

Background: Surveillance of antimicrobial resistance (AMR) requires an international approach with national and local strategies. Our aim was to summarize a retrospective 10-year report of antibiotic resistance of gram-positive and gram-negative bacteria in Mexico. Methods: A total of 46 centers from 22 states of Mexico participated. Databases of AMR from January 2009 to December 2018 were included for most species. The 10-year period was divided into five 2-year periods. Results: For Staphylococcus aureus, a decrease in resistance in all specimens was observed for erythromycin and oxacillin (p < 0.0001 for each). For Enterobacter spp., resistance to meropenem increased for urine specimens (p = 0.0042). For Klebsiella spp., increased drug resistance in specimens collected from blood was observed for trimethoprim/sulfamethoxazole, gentamicin, tobramycin (p < 0.0001 for each), meropenem (p = 0.0014), and aztreonam (p = 0.0030). For Acinetobacter baumannii complex, high drug resistance was detected for almost all antibiotics, including carbapenems, except for tobramycin, which showed decreased resistance for urine, respiratory, and blood isolates (p < 0.0001 for each), and for amikacin, which showed a decrease in resistance in urine specimens (p = 0.0002). An increase in resistance to cefepime was found for urine, respiratory, and blood specimens (p < 0.0001 for each). For Pseudomonas aeruginosa, aztreonam resistance increased for isolates recovered from blood (p = 0.0001). Conclusion: This laboratory-based surveillance of antibiotic resistance shows that resistance is increasing for some antibiotics in different bacterial species in Mexico and highlights the need for continuous monitoring of antibiotic resistance.