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Utilizing the CF 2 H Moiety As a H-bond-donating Group in Drug Discovery

2020; Future Science Ltd; Volume: 12; Issue: 5 Linguagem: Inglês

10.4155/fmc-2019-0309

1756-8927

Yossi Zafrani, Sigal Saphier, Eytan Gershonov,

Click Chemistry and Applications

Future Medicinal ChemistryVol. 12, No. 5 CommentaryUtilizing the CF2H moiety as a H-bond-donating group in drug discoveryYossi Zafrani, Sigal Saphier & Eytan GershonovYossi Zafrani*Author for correspondence: E-mail Address: yossiz@iibr.gov.ilThe Department of Organic Chemistry, Israel Institute for Biological Research, Ness-Ziona 74100, Israel, Sigal SaphierThe Department of Organic Chemistry, Israel Institute for Biological Research, Ness-Ziona 74100, Israel & Eytan GershonovThe Department of Organic Chemistry, Israel Institute for Biological Research, Ness-Ziona 74100, IsraelPublished Online:6 Feb 2020https://doi.org/10.4155/fmc-2019-0309AboutSectionsView ArticleView Full TextPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareShare onFacebookTwitterLinkedInReddit View articleKeywords: bioisosteredifluoromethyldrug designhydrogen bondReferences1. Meanwell NA. 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This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.No writing assistance was utilized in the production of this manuscript.PDF download