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Quantification of DNA Double Strand Breaks and Oxidation Response in Children and Adults Undergoing Dental CBCT Scan

2020; Nature Portfolio; Volume: 10; Issue: 1 Linguagem: Inglês

10.1038/s41598-020-58746-5

2045-2322

Niels Belmans, Liese Gilles, Randy Vermeesen, Piroska Virág, Mihaela Hedeșiu, Benjamin Salmon, Sarah Baatout, Stéphane Lucas, Ivo Lambrichts, Reinhilde Jacobs, Marjan Moreels, Anne Caroline Costa Oenning, Catherine Chaussain, C. Lefevre, Mihaela Băciuț, Marius Marcu, Oana Almășan, Raluca Roman, Ioan Barbur, Cristian Dinu, Horaţiu Rotaru, Lucia Hurubeanu, Vlad Istouan, Ondine Lucaciu, Daniel-Corneliu Leucuţa, Bogdan Crișan, L. Bogdan, Ciprian Cândea, Simion Bran, Grigore Băciuţ, Hilde Bosmans, Ria Bogaerts, Constantinus Politis, Andreas Stratis, Ruben Pauwels, Karla de Faria Vasconcelos, Laura Ferreira Pinheiro Nicolielo, G. Zhang, E. Tijskens, Myrthel Vranckx, Anna Ockerman, E. Claerhout, E. Embrechts,

Oral health in cancer treatment

Abstract Assessing the possible biological effects of exposure to low doses of ionizing radiation (IR) is one of the prime challenges in radiation protection, especially in medical imaging. Today, radiobiological data on cone beam CT (CBCT) related biological effects are scarce. In children and adults, the induction of DNA double strand breaks (DSBs) in buccal mucosa cells and 8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxo-dG) and antioxidant capacity in saliva samples after CBCT examination were examined. No DNA DSBs induction was observed in children nor adults. In children only, an increase in 8-oxo-dG levels was observed 30 minutes after CBCT. At the same time an increase in antioxidant capacity was observed in children, whereas a decrease was observed in adults. Our data indicate that children and adults react differently to IR doses associated with CBCT. Fully understanding these differences could lead to an optimal use of CBCT in different age categories as well as improved radiation protection guidelines.