Metal complexes as a promising source for new antibiotics
2020; Royal Society of Chemistry; Volume: 11; Issue: 10 Linguagem: Inglês
10.1039/c9sc06460e
ISSN2041-6539
AutoresAngelo Frei, Johannes Zuegg, Alysha G. Elliott, Murray V. Baker, Stefan Braese, Christopher A. Brown, Feng Chen, Christopher G. Dowson, Gilles Dujardin, Nicole Jung, Anna King, Ahmed M. Mansour, Massimiliano Massi, John Moat, Heba Mohamed, Anna K. Renfrew, Peter J. Rutledge, Peter J. Sadler, Matthew H. Todd, Charlotte E. Willans, Justin J. Wilson, Matthew A. Cooper, Mark A. T. Blaskovich,
Tópico(s)Synthesis and Biological Evaluation
ResumoThere is a dire need for new compounds to combat antibiotic resistance: metal complexes might provide the solution. 906 metal complexes were evaluated against dangerous ESKAPE pathogens and found to have a higher hit-rate than organic molecules.
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