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Targeting glioma-initiating cells via the tyrosine metabolic pathway

2020; American Association of Neurological Surgeons; Volume: 134; Issue: 3 Linguagem: Inglês

10.3171/2019.11.jns192028

1933-0693

Daisuke Yamashita, Joshua D. Bernstock, Galal Elsayed, Hirokazu Sadahiro, Ahmed Mohyeldin, Gustavo Chagoya, Adeel Ilyas, James Mooney, Dagoberto Estévez-Ordoñez, Shinobu Yamaguchi, Victoria L. Flanary, James R. Hackney, Krishna Bhat, Harley I. Kornblum, Nicola Zamboni, Sung-Hak Kim, E. Antonio Chiocca, Ichiro Nakano,

Epigenetics and DNA Methylation

Despite an aggressive multimodal therapeutic regimen, glioblastoma (GBM) continues to portend a grave prognosis, which is driven in part by tumor heterogeneity at both the molecular and cellular levels. Accordingly, herein the authors sought to identify metabolic differences between GBM tumor core cells and edge cells and, in so doing, elucidate novel actionable therapeutic targets centered on tumor metabolism.