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Investigation of Photostability of Istradefylline Aqueous Solution

2020; Wiley; Volume: 5; Issue: 7 Linguagem: Inglês

10.1002/slct.201904148

2365-6549

Haojie Xu, Yiyun Wang, Hongyi Wang, Zhonghui Zheng, Zihui Meng, Min Xue, Zhibin Xu,

Luminescence and Fluorescent Materials

ChemistrySelectVolume 5, Issue 7 p. 2337-2341 Full Paper Investigation of Photostability of Istradefylline Aqueous Solution Dr. Haojie Xu, Dr. Haojie Xu School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing, 100081 China Shandong Xinhua Pharmaceutical Co., Ltd. No.1 Lutai avenue, 255086, ZiBo Shandong, ChinaSearch for more papers by this authorDr. Yiyun Wang, Dr. Yiyun Wang School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing, 100081 China Shandong Xinhua Pharmaceutical Co., Ltd. No.1 Lutai avenue, 255086, ZiBo Shandong, ChinaSearch for more papers by this authorHongyi Wang, Hongyi Wang School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing, 100081 China Shandong Xinhua Pharmaceutical Co., Ltd. No.1 Lutai avenue, 255086, ZiBo Shandong, ChinaSearch for more papers by this authorDr. Zhonghui Zheng, Dr. Zhonghui Zheng Shandong Xinhua Pharmaceutical Co., Ltd. No.1 Lutai avenue, 255086, ZiBo Shandong, ChinaSearch for more papers by this authorProf. Zihui Meng, Corresponding Author Prof. Zihui Meng m_zihui@yahoo.com orcid.org/0000-0002-2751-0057 School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing, 100081 ChinaSearch for more papers by this authorProf. Min Xue, Prof. Min Xue School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing, 100081 ChinaSearch for more papers by this authorProf. Zhibin Xu, Prof. Zhibin Xu School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing, 100081 ChinaSearch for more papers by this author Dr. Haojie Xu, Dr. Haojie Xu School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing, 100081 China Shandong Xinhua Pharmaceutical Co., Ltd. No.1 Lutai avenue, 255086, ZiBo Shandong, ChinaSearch for more papers by this authorDr. Yiyun Wang, Dr. Yiyun Wang School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing, 100081 China Shandong Xinhua Pharmaceutical Co., Ltd. No.1 Lutai avenue, 255086, ZiBo Shandong, ChinaSearch for more papers by this authorHongyi Wang, Hongyi Wang School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing, 100081 China Shandong Xinhua Pharmaceutical Co., Ltd. No.1 Lutai avenue, 255086, ZiBo Shandong, ChinaSearch for more papers by this authorDr. Zhonghui Zheng, Dr. Zhonghui Zheng Shandong Xinhua Pharmaceutical Co., Ltd. No.1 Lutai avenue, 255086, ZiBo Shandong, ChinaSearch for more papers by this authorProf. Zihui Meng, Corresponding Author Prof. Zihui Meng m_zihui@yahoo.com orcid.org/0000-0002-2751-0057 School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing, 100081 ChinaSearch for more papers by this authorProf. Min Xue, Prof. Min Xue School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing, 100081 ChinaSearch for more papers by this authorProf. Zhibin Xu, Prof. Zhibin Xu School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing, 100081 ChinaSearch for more papers by this author First published: 19 February 2020 https://doi.org/10.1002/slct.201904148Citations: 1Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Graphical Abstract It was found that Istradefylline aqueous solution were extremely unstable in light. Compared with the Istradefylline peak, the impurity peak increased from 39.6% at 5 minutes to 81.3% at 24 hours. It is proved that light has great influence on the stability of Istradefylline. The impurity was separated by preparative HPLC, and further characterized by MS and NMR as Z-Istradefylline, a photo degradation product of Istradefylline. Abstract Istradefylline is a selective adenosine antagonist for A2a receptor, and it is used to treat Parkinson's syndrome and improve dyskinesia in the early stage of Parkinson's disease. Istradefylline aqueous solution were preserved in darkness and light respectively, and it was found that Istradefylline aqueous solution were extremely unstable in light. An impurity of Istradefylline was identified by HPLC and further collected by preparative HPLC. The impurity was characterized by NMR and MS and identified as Z-Istradefylline, a photo degradation product of Istradefylline. The founding of degradation phenomenon makes the research on the stability of Istradefylline aqueous solution absolutely necessary for the quality control of the drug. Citing Literature Supporting Information As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Filename Description slct201904148-sup-0001-misc_information.pdf718.7 KB Supplementary Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article. Volume5, Issue7February 21, 2020Pages 2337-2341 RelatedInformation