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Sociodemographic and Reproductive Risk Factors for Breast Cancer: A Case-Control Study in the Setif Province, Northern Algeria

2020; West Asia Organization for Cancer Prevention; Volume: 21; Issue: 2 Linguagem: Inglês

10.31557/apjcp.2020.21.2.457

2476-762X

M Hamdi-Chérif, Diego Serraino, Souad Bouad, Adlane Dib, Khadidja Boudaoud, Saida Atoui, Imene Mergherm, Federica Toffolutti, Ettore Bidoli, Rengaswamy Sankaranarayanan, Asma Ayat, Ghania Habia, Kenza Makhloufi, Imane Bouchaibi, Sabah Kettaf, Samiha Chenafi, Douniazad Dilmi, Karima Bouhafs, Bahadinne Ablaoui, Hadjira Chaouche, Loubna Belbedj, Asma Nadjem, Nawel Lakab, Saverio Virdone, Chiara Panato,

Multiple and Secondary Primary Cancers

Background: The age-standardized rate of breast cancer (BC) increased nearly nine-fold in the last 30 years in Setif, Algeria. A case-control study was carried out to investigate the role of sociodemographic characteristics and reproductive factors in the etiology of BC in this young Arab/Berber population of Setif. Methods: Cases were 612 women with incident BC admitted to major teaching and general hospitals of Setif during 2012–2017. Controls were 615 women admitted for acute, non-neoplastic conditions to the same hospital network of cases. Information was elicited using a standardized questionnaire. Odds ratios (ORs) and 95% confidence intervals (CIs) were computed after allowance for age and education. Results: Significant associations with BC risk emerged for family history of BC (OR= 4.15 for yes vs. no; 95%CI: 2.22-7.77), for the generation of oral contraceptive used (OR=1.57 for II-generation vs. III-generation; 95%CI:1.01-2.44), and education (OR=0.63 for >11 years vs. no schooling; 95%CI: 0.46-0.86). Conversely, parity and body mass index were not associated with BC risk, whereas a late age at menarche was linked with a non statistically significant BC risk (OR=1.20 for >15 vs.