Synthesis of Silver-Coated Bioactive Nanocomposite Scaffolds Based on Grafted Beta-Glucan/Hydroxyapatite via Freeze-Drying Method: Anti-Microbial and Biocompatibility Evaluation for Bone Tissue Engineering
2020; Multidisciplinary Digital Publishing Institute; Volume: 13; Issue: 4 Linguagem: Inglês
10.3390/ma13040971
ISSN1996-1944
AutoresMuhammad Umar Aslam Khan, Mesfer A. Al-Thebaiti, Muhammad Uzair Hashmi, Saira Aftab, Saiful Izwan Abd Razak, Shukur Abu Hassan, Mohammed Rafiq Abdul Kadir, Rashid Amin,
Tópico(s)biodegradable polymer synthesis and properties
ResumoAdvancement and development in bone tissue engineering, particularly that of composite scaffolds, are of great importance for bone tissue engineering. We have synthesized polymeric matrix using biopolymer (β-glucan), acrylic acid, and nano-hydroxyapatite through free radical polymerization method. Bioactive nanocomposite scaffolds (BNSs) were fabricated using the freeze-drying method and Ag was coated by the dip-coating method. The scaffolds have been characterized by Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), and X-ray diffraction analysis (XRD) to investigate their functional groups, surface morphology, and phase analysis, respectively. The pore size and porosity of all BNS samples were found to be dependent on silver concentration. Mechanical testing of all BNS samples have substantial compressive strength in dry form that is closer to cancellous bone. The samples of BNS showed substantial antibacterial effect against DH5 alpha
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