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Demographic and Clinicopathologic Features of Actinic Cheilitis and Lip Squamous Cell Carcinoma: a Brazilian Multicentre Study

2020; Springer Science+Business Media; Volume: 14; Issue: 4 Linguagem: Inglês

10.1007/s12105-020-01142-2

1936-0568

Leni Verônica de Oliveira Silva, José Alcides Almeida de Arruda, Lucas Guimarães Abreu, Raquel Conceição Ferreira, Leorik Pereira da Silva, Cibele Pelissari, Ricardo Natã Fonseca Silva, Kaio Heide Sampaio Nóbrega, Bruno Augusto Benevenuto de Andrade, Mário José Romañach, Michelle Agostini, Cassiano Francisco Weege Nonaka, Pollianna Muniz Alves, Hélder Antônio Rebelo Pontes, Luís Fernando da Rosa Rivero, Lélia Batista de Souza, Marília Trierveiler Martins, Elismauro Francisco Mendonça, Ana Paula Neutzling Gomes, Manoela Domingues Martins, Emanuel Sávio de Souza Andrade, Márcia Maria Fonseca da Silveira, Ana Paula Veras Sobral, Ricardo Alves Mesquita,

Tumors and Oncological Cases

Data on the occurrence and clinicopathological characteristics of actinic cheilitis (AC) and lip squamous cell carcinoma (LSCC) are well studied; however, they are based on studies limited to a single centre. Herein, we described the frequency of AC and LSCC submitted to microscopic examination from representative geographic regions of Brazil. A retrospective multicentre study was performed on biopsies obtained from 1953 to 2018 at 10 Brazilian oral and maxillofacial pathology centres. A total of 198,709 biopsy specimens were surveyed. Sociodemographic data and clinicopathologic characteristics were analysed. A total of 2017 cases of ACs (1.0%) and 850 cases of LSCCs (0.4%) were recorded. A strong fair-skinned (> 87%) male (> 70%) predilection was observed in both conditions. The mean age was 54.8 ± 18.7 for individuals with AC and 57.8 ± 19.0 for individuals with LSCC. The most commonly affected site was the lower lip (> 90%). This is a large multicentre study of AC and LSCC from Brazil. The frequency and clinicopathological features of AC and LSCC were similar to those described worldwide. This study provides robust and representative epidemiological data of these conditions for the scientific community.