Portal de Periódicos da CAPES

Patterns of sensitization to inhalant allergens, Ole e 1 and Ole e 7 in children and adolescents born in the same area with different origin.

2020; Elsevier BV; Volume: 145; Issue: 2 Linguagem: Inglês

10.1016/j.jaci.2019.12.514

1097-6825

Maria Somoza Alvarez, Laura Victorio Puche, Natalia Blanca‐López, Francisco Javier Ruano, María Vázquez de la Torre, Isabel Torres Rojas, José Damián López Sánchez, María Garrido‐Arandia, Laura Martín‐Pedraza, Araceli Díaz‐Perales, Mayte Villalba, Gabriela Canto Díez, Miguel Blanca,

Indoor Air Quality and Microbial Exposure

Sensitization and allergy can start at early ages with genetic and epigenetic background and environmental factors involved. To study the sensitization and clinical relevance to the most prevalent inhalant allergens plus the molecular components of Olea europaea, Ole e 1 and Ole e 7, in children/adolescents born in the same area but of different ethnicities and to establish the relationship with sensitization in their parents. Spanish and Moroccan children/adolescents (3-19 years) born in Blanca (Murcia, South-East Spain) who have spent all their life-time there were evaluated. Skin prick tests were done to prevalent pollens, Ole e 1 and Ole e 7 and a detailed questionnaire given. Results were compared with those of their parents. The study included 693 subjects, 48% aged 3-9 years and 52% 10-19 years Sensitization to O. europaea, P. pratense, S. kali and C arizonica were slightly higher in the Spanish group but with no statistical significance. The only significant differences were observed in sensitization to Ole e 1 (p<0.02). The clinical entities rhinitis, conjunctivitis and asthma, either alone or in combination, were significantly higher in the Spanish group. Sensitization differed between Spanish and Moroccan parents and between Moroccan parents and their children but not between Spanish parents and their children. These data suggest that the environment has a stronger influence than ancestry in the induction of sensitization and that other factors may contribute to the differences in prevalence in the clinical entities observed between the populations studied.