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Epidemiology, clinical features and diagnostic work-up of cystic neoplasms of the pancreas: Interim analysis of the prospective PANCY survey

2020; Elsevier BV; Volume: 52; Issue: 5 Linguagem: Inglês

10.1016/j.dld.2020.02.003

1878-3562

Raffaele Pezzilli, Elisabetta Buscarini, Tommaso Pollini, Deborah Bonamini, Giovanni Marchegiani, Stefano Crippa, Giulio Belfiori, Cosimo Sperti, Lucia Moletta, G Pozza, Germana De Nucci, G. Manes, Enzo Domenico Mandelli, Riccardo Casadei, Claudio Ricci, Saverio Alicante, C. Vattiato, Silvia Carrara, Milena Di Leo, Carlo Fabbri, S. Giovanelli, Luca Barresi, Matteo Tacelli, V.G. Mirante, Rita Conigliaro, Filippo Antonini, Giampiero Macarri, Luca Frulloni, Giulia De Marchi, Romano Sassatelli, Paolo Cecinato, G. Del Vecchio Blanco, Andrea Galli, Angelo Maria Pezzullo, Alberto Fantin, Massimo Graffeo, Mauro Frego, D. Stillittano, Fabio Monica, Bastianello Germanà, Gabriele Capurso, Mariano Quartini, Luigi Veneroni, Renato Cannizzaro, Massimo Falconi,

Gastrointestinal disorders and treatments

Introduction A prospective survey to evaluate the diagnostic workup of cystic pancreatic neoplasms (CPNs) according to the Italian guidelines. Methods An online data sheet was built. Results Fifteen of the 1385 patients (1.1%) had non cystic neoplastic lesions. Forty percent (518/1295) had at least one 1st degree relative affected by a solid tumor of the digestive and extra-digestive organs. Symptoms/signs associated with the cystic lesion were present in 24.5% of the patients. The cysts were localized in the head of the pancreas in 38.5% of patients. Of the 2370 examinations (1.7 examinations per patient) which were carried out for the diagnosis, magnetic resonance imaging was performed as a single test in 48.4% of patients and in combination with endoscopic ultrasound in 27% of the cases. Of the 1370 patients having CPNs, 89.9% had an intraductal papillary mucinous neoplasm (IPMN) (70.1% a branch duct IPMN, 6.2% a mixed type IPMN and 4.6% a main duct IPMN), 12.7% had a serous cystadenoma, 2.8% a mucinous cystadenoma, 1.5% a non-functioning cystic neuroendocrine neoplasm, 0.7% a solid-pseudopapillary cystic neoplasm, 0.3% a cystic adenocarcinoma, and 1.2% an undetermined cystic neoplasm. Seventy-eight (5.7%) patients were operated upon after the initial work-up. Conclusions This prospective study offers a reliable real-life picture of the diagnostic work-up CPN.