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Neoplasic Disease and Chronic Kidney Disease: Does the Association Worsen Prognosis?

2012; Elsevier BV; Volume: 23; Linguagem: Inglês

10.1016/s0923-7534(20)33961-2

1569-8041

Daniel Romeira, C.T. Carvalho, M. Fernanda R. P. Proença, M. Alface, Rosa Cardiga, Ana Rita Ferreira, Ana Carla Carneiro Leitão, Cassiane Dezoti da Fonseca, Fátima Ceia, Alice Maria Costa Martins,

Parathyroid Disorders and Treatments

ABSTRACT Neoplastic diseases (ND) and chronic kidney disease (CKD) are strongly related. Side effects of neoplastic treatments can cause CKD and the latter can be a risk factor for ND. Even in early stages of CKD, the risk of developing ND increases, the latter being drastically increased in patients (pts) treated with hemodialysis. Objectives Compare, within a population of cancer pts with and without CKD, demographic characteristics, length of hospital stay, and prognosis. Methods Observational prospective study with all consecutively admitted pts in an Internal Medicine department of a CentralHospital between November 2010 and October 2011. Collection of data using a previously normalized questionnaire, completed on admission and date of release, finalized with a posterior telephonic contact. The following characteristics of pts with ND and CKD (GFR CKD Results We evaluated 104 pts with ND with an average follow-up of 162 days.GA= 40 pts (38,5%) 78,9 ± 10,6 years, 52,5% women, GFR =39,6 ±12 mL/min/1,73m2, stages III = 77,5%, IV = 22,5% GB= 64 pts (61,5%), 72,92 ± 12,6 years; 46,9% women, GFR = 72,9 ± 14,5mL/min/1,73m2. Hospital stay length: GA 9,2 ± 5 vs GB 9.9 ± 9,3 days. Hospital stay mortality: GA: 27,5% VS GB: 3,125%. CKD correlates with hospital-stay mortality: (χ2(2) = 13,371; p = 0,000 N = 104.); Significant differences were found between both groups pertaining to average survival during follow-up: (t(52) = -3,437; p = 0,01). The average length of hospital-stay and the number of readmissions are not related to the existence of CKD: (χ2(2) = 0,399; p = 0,53 N = 90) Conclusion More than 1/3 of ND pts had CKD, the majority within stage III. ND pts with CKD were older. CKD contributed to hospital stay mortality and shorter survival rate on follow-up of pts with ND but did not contribute to an increase of hospital stay length. Disclosure All authors have declared no conflicts of interest.